Infections caused by KPC-producing bacteria can be difficult to treat because fewer antibiotics are effective against them. In such cases, a microbiology laboratory must run tests to determine which antibiotics will treat the infection. They must follow the treatment regimen prescribed by the healthcare provider. If the healthcare provider prescribes an antibiotic, patients must take it exactly as the healthcare provider instructs.
Patients must complete the prescribed course of medication, even if symptoms are gone. If treatment stops too soon, some bacteria may survive and the patient may become re-infected. Patients must wash their hands as often as possible and follow all other hygiene recommendations.
The healthcare provider will order laboratory tests to determine if the Klebsiella infection is drug-resistant. If family members are healthy, they are at very low risk of acquiring a Klebsiella infection. It is still necessary to follow all precautions, particularly hand hygiene. Klebsiella bacteria are spread mostly by person-to-person contact and hand hygiene is the best way to prevent the spread of germs.
Skip directly to site content Skip directly to page options Skip directly to A-Z link. Healthcare-associated Infections. Section Navigation. Facebook Twitter LinkedIn Syndicate. Klebsiella pneumoniae in Healthcare Settings. The magnetic susceptibility of these products results in a possibility of magnetic control being exerted over them. Klebsiella oxytoca is known to breakdown cyanide, a chemical that is extremely toxic to humans.
Wastewater that contains cyanide must be treated before it is released into the environment and the current methods of treating the water e. Tang et al. Electrophoresis and computer analysis were used to identify proteins. Some of the proteins were excised and further testing was perfromed to extract them and identify them using the NCBI database. The researchers identified 27 proteins that are known to be involved with carbohydrate, nucleotide, amino acid, and nitrogen metabolism, and oxidation-reduction reactions Klebsiella oxytoca was determined to be the cause of spontaneous arthritis in the knee of a month old child with no prior history of any bacterial infections 6.
The child had not been hospitalized recently, was up to date on all vaccinations, and did not present with a urinary tract infection. Normally, cases of spontaneous arthritis in children are associated with Staphylococcus aureus , Kingella kingae , and Streptococcus pneumonia 6.
The patient was treated with antibiotics specific to each of those bacteria, respectively, which ultimately proved to be ineffective. The bacteria present in the synovial fluid of the knee was finally identified as K.
The antibiotics, ceftriaxone and amikacin, were used for two days, then switched solely to ceftriaxone due to the results from antimicrobial susceptibility testing 6. X-rays taken post-antibiotic treatment showed a complete recovery in the child's knee. Klebsiella Infections. Medscape Reference. Klebsiella species K. ESBL ; [accessed Feb Journal of Clinical Microbiology. Volume Clinical Microbial Revue. Physics of the Solid State.
Endogenous Klebsiella endophthalmitis: case report. Mt Sinai J Med ; Infections caused by Klebsiella ozaenae : a changing disease spectrum. BMS formerly T, a des-fluoroquinolone potency and spectrum tested against over 10, bacterial bloodstream infection isolates from the SENTRY antimicrobial surveillance program Multi-resistant Klebsiella in Grampian.
Green M, Barbadora K. Recovery of ceftazidime-resistant Klebsiella pneumoniae from pediatric liver and intestinal transplant recipients. Pediatr Transplant ; Sulfamethoxazole-trimethoprim for infections in cancer patients. JAMA ; The post-antibiotic effect induced by antimicrobial combinations. Scand J Infect Dis - Suppl ; A statistical evaluation of the bactericidal effects of ceftibuten in combination with aminolgycosides and ciprofloxacin.
Klebsiella pneumoniae bacteremia in the community hospital. J Fam Prac ; Intensive care management of community- acquired Klebsiella pneumoniae. Respir Med ; Han SH. Review of hepatic abscess from Klebsiella pneumoniae.
An association with diabetes mellitus and septic endophtalmitis. West J Med ; In vitro and in vivo antibacterial activities of meropenem, a new carbapenem antibiotic. Drugs Exp Clin Research ; Monoclonal antibody against Klebsiella capsular polysaccharide reduces severity and hematogenic spread of experimental Klebsiella pneumoniae pneumonia. Infect Immunity ; Klebsiella pneumoniae meningitis. Intravenous trimethoprim- sulfamethoxazole treatment.
A case of liver abscess associated with endophthalmitis caused by Klebsiella pneumoniae. A case of gas-containing liver abscess with multiple metastatic lesions.
Friedlander's pneumonia. A report of 11 cases and appraisal of antibiotic therapy. Dis Chest ; Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women. Combination effect of SCE and cefepime with aminoglycosides on nosocomial gram-negative bacteria.
A compilation of meropenem tissue distribution data. J Antimicrob Chemother ;36 Suppl A In vitro pharmacodynamics of piperacillin, piperacillin- tazobactam, and ciprofloxacin alone and in combination against Staphylococcus aureus, Klebsiella pneumoniae , Enterobacter cloacae, and Pseudomonas aeruginosa.
More extended-spectrum beta-lactamases. Jacoby GA, Sutton L. Properties of plasmids responsible for production of extended-spectrum beta- lactamases.
Isolation of Klebsiella ozaenae from a corneal abscess. Am J Clinic Pathol ; In vitro activities of various beta-lactam antimicrobial agents against clinical isolates of Escherichia coli and Klebsiella species resistant to oxyimino cephalosporins.
Jones RN. In vitro evaluation of ertapenem MK , a long-acting carbapenem, tested against selected resistant strains. J Chemother ; Diagn Microbiol Infect Dis. Rapidly fatal outcome of bacteremic Klebsiella pneumoniae pneumonia in alcoholics. Chest ; Piperacillin with and without tazobactam against extended-spectrum beta-lactamase-producing Pseudomonas aeruginosa in a rat thigh abscess model.
Pneumonia caused by Gram negative bacilli. Am J Med ; Optimizing aminoglycoside therapy for nosocomial pneumonia caused by Gram-negative bacteria.
The intravitreal penetration of orally administered ciprofloxacin in humans. Invest Ophthalmol Vis Sci ; Aztreonam for treating meningitis caused by gram-negative rods. Scand J Inf Dis ; Antimicrobial activity of tobramycin and gentamicin used in combination with cephalothin and carbenicillin. Synergism between amikacin and cefazolin against Klebsiella : in vitro studies and effect on the bactericidal activity of serum. Effectiveness of the carbenicillin-cephalothin combination against gram-negative bacilli.
Comparative effects of cefpirome HR and other cephalosporins on experimentally induced pneumonia in mice. J Antibiotics ; Evolution of plasmid-coded resistance to broad-spectrum cephalosporins. Klugman KP, Dagan R. Randomized comaprison of meropenem with cefotaxime for treatment of bacterial meningitis. Meropenem Meningitis Study Group.
Massive pulmonary gangrene: a severe complication of Klebsiella pneumonia. Canad Med Assoc J ; Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Community- acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns.
Emerg Infect Dis ; In vitro activities of the potent, broad-spectrum carbapenem MK L, against broad-spectrum beta-lactamase and extended-spectrum beta-lactamase producing Klebsiella pneumoniae and Escherichia coli clinical isolates. Prospective observational study of Klebsiella bacteremia in patients: outcome for antibiotic combinations versus monotherapy. Klebsiella pneumonia in the modern era: clinicoradiographic correlations. Klebsiella metastatic endophthalmitis - a complication of shock wave lithotripsy.
Ophthal Surg ; Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid and sulbactam.
Serum bactericidal activity of ceftazidime increased by netilmicin. Drug Intell Clin Pharm ; Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics. Am J Gastroenterol ; Comparative dose-effect relations at several dosing intervals for beta-lactam, aminoglycoside and quinolone antibioitcs against gram-negative bacilli in murine thigh-infection and pneumonitis models.
Scand J Infect Dis ;74 Suppl Antibiotics, biliary sepsis and bile duct stones. Gastrointest Endoscopy ; Cerebrospinal fluid penetration of trimethoprim-sulfamethoxazole in two patients with gram-negative bacillary meningitis. J Antimicrob Chemother a; Levitz RE, Quintiliani R. Trimethoprim-sulfamethoxazole for bacterial meningitis.
Ann Int Med b; Endogenous Klebsiella pneumoniae endophthalmitis in diabetic patients. Canadian J Ophthalmol ; High prevalence of phagocytic-resistant capsular serotypes of Klebsiella pneumoniae in liver abscess.
Microbes Infect ; Acute cholangitis. Surg Clin North Amer ; Livermore DM. Beta-lactamases in laboratory and clinical resistance. Clin Microbiol Rev ; Activity of ertapenem MK versus Enterobacteriaceae with potent beta-lactamases. Control of a prolonged outbreak of extended-spectrum beta-lactamase-producing Enterobacteriaceae in a university hospital. Emergence of a carbapenem-resistant Klebsiella pneumoniae. Recurrent Klebsiella meningitis following trans-sphenoidal hypophysectomy for Nelson's syndrome.
Chloramphenicol resistance during relapse. Henry Ford Hosp Med J ; Activity of isepamicin and selection of permeability mutants to beta-lactams during aminoglycoside therapy of experimental endocarditis due to Klebsiella pneumoniae CF producing an aminoglycoside acetyltransferase 6' modifying enzyme and a TEM-3 beta-lactamase.
Murine monoclonal antibodies to Klebsiella pneumoniae protect agaisnt lethal endotoxemia and experimental infection with capsulated K. Infect Immun ; Endogenous Klebsiella endophthalmitis. Report of two cases and review of the literature. Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae.
Quinolone resistance from a transferable plasmid. Septic endophthalmitis associated with bacteremia and liver abscess caused by Klebsiella pneumoniae. Boletin - Asociacion Medica de Puerto Rico ; Bacteriostatic and bactericidal activities of beta-lactam antibiotics enhanced by the addition of low concentrations of gentamicin. Piperacillin, tazobactam and gentamicin alone or combined in an endocarditis model of infection by a TEM-3 producing strain of Klebsiella pneumoniae or its susceptible variant.
Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Ann Intern Med ; In vitro activities of sitafloxacin DUa and six other fluoroquinolones against 8, clinical bacterial isolates. Treatment of experimental pneumonia in rats caused by a PER-1 extended-spectrum beta-lactamase-producing strain of Pseudomonas aeruginosa. Emergence of clinical Escherichia coli isolates with decreased susceptibility to ceftazidime and synergic effect with co-amoxiclav due to SHV-1 hyperproduction.
Difficulties in identifying Klebsiella strains of clinical origin. Int J Med Microbiol ; Complications of Klebsiella pneumonia: CT evaluation. J Computer Assist Tomog ; Mulgrave L, Attwood PV. Characterization of an SHV-5 related extended broad spectrum beta- lactamase in Enterobacteriaceae from Western Australia.
Pathology ; Efficacy of meropenem in experimental meningitis. Cefotaxime therapy of neonatal gram-negative bacillary meningitis. Pediatr Inf Dis ; Outbreak of ceftazidime resistance due to a novel extended spectrum beta-lactamase in isolates from cancer patients. Nicolas-Chanoine MH. Inhibitor-resistant beta-lactamases.
Successful treatment of ozena with ciprofloxacin. Rhinology ; Nishino T, Obana Y. Therapeutic efficacy of intravenous and oral ciprofloxacin in experimental murine infections. Safety profile of meropenem: international clinical experience based on the first patients treated with meropenem. Clinicopathological analysis of liver abscess in Japan. Int J Mol Med ; In vivo selection of a cephamycin-resistant, porin-deficient mutant of Klebsiella pneumoniae producing a TEM-3 beta- lactamase.
Klebsiella species: antimicrobial susceptibilities, bactericidal kinetics, and in vitro inactivation of beta-lactam antibiotics. Control of an outbreak of infection due to extended-spectrum beta-lactamase-producing Escherichia coli in a liver transplantation unit. Fatal infection due to extended-spectrum beta- lactamase producing Escherichia coli : implications for antibiotic choice for spontaneous bacterial peritonitis. Paterson DL. Recommendations for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum beta-lactamases ESBLs.
Clin Microbiol Infect ; Extended-spectrum beta-lactamases: a call for improved detection and control. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases ESBLs : implications for the clinical microbiology laboratory. Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia.
Clin Infect Dis. Association of antibiotic utilization measures and control of multiple drug resistance in Klebsiella pneumoniae. Infect Control Hosp Epidemiol ; Infection due to Klebsiella rhinoscleromatis in two patients infected with human immunodeficiency virus.
Clin Inf Dis ; Exogenous endophthalmitis initially treated without systemic antibiotics. Mutants of the TEM-1 beta-lactamase conferring resistance to ceftazidime. Risk factors for faecal carriage of Klebsiella pneumoniae producing extended spectrum beta-lactamase ESBL-KP in the intensive care unit. J Hosp Infect ; In vitro activities of streptomycin and 11 oral antimicrobial agents against clinical isolates of Klebsiella rhinoscleromatis.
Plasmid-determined AmpC-type beta-lactamases. Extended-spectrum beta-lactamases. Am J Perinatol ; Podbielski A, Melzer B. Nucleic Acids Research ; Characterization of Klebsiella terrigena strains from humans: haemagglutinins, serum resistance, siderophore synthesis, and serotypes. Epidemiol Infect ; Podschun R , Ullman U. Clin Micro Rev ; Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.
Influence of dosage interval on the therapeutic response to gentamicin in mice infected with Klebsiella pneumoniae. Novel plasmid-mediated beta-lactamase TEM- 10 conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. Pyogenic liver abscess: recent trends in etiology and mortality. Comparison of single-dose administration and three-day course of amoxicillin with those of clavulanic acid for treatment of uncomplicated urinary tract infection in women.
High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae. Molecular genetics of resistance to both ceftazidime and beta-lactam-beta-lacatamase inhibitor combinations in Klebsiella pneumoniae and in vivo response to beta-lactam therapy.
Outbreak of ceftazidime resistance caused by extended spectrum beta-lactamases at a Massachusetts chronic-care facility. Efficacy of different beta-lactams against an extended spectrum beta-lactamase producing Klebsiella pneumoniae strain in the rat intra- abdominal abscess model. Nosocomial infections in medical intensive care units in the United States. Crit Care Med ; Comparative activity of cefepime, ceftazidime and imipenem in a mouse infection caused by Klebsiella pneumoniae producing a broad spectrum beta-lactamase.
Pathol Biol ; Continuous versus intermittent administartion of ceftazidime in experimental Klebsiella pneumoniae pneumonia in normal and leukopenic rats. Comparative activities of ciprofloxacin and ceftazidime against Klebsiella pneumoniae in vitro and in experimental pneumonia in leukopenic rats.
Antimicrob Agents Chemother ; Bactericidal effect of beta-lactams and amikacin alone or in association against Klebsiella pneumoniae producing extended spectrum beta-lactamase. Beta-lactam reistance in Gram-negative bacteria: global trends and clinical impact. Successful treatment of hospital acquired Klebsiella pneumoniae meningitis in a neonate with ciprofloxacin. Indian Pediatr ; Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli bloodstream infection: A case-control and molecular epidemiologic investigation.
Therapeutic efficacy of liposome-encapsulated gentamicin in rat Klebsiella pneumoniae pneumonia in relation to impaired host defense and low bacterial susceptibility to gentamicin. A randomised comparison of meropenem with cefotaxime or ceftriaxone for the treatment of bacterial meningitis in adults. Successful treatment of ceftazidime-resistant Klebsiella pneumoniae ventriculitis with intravenous meropenem and intraventricular polymyxin B: Case report and review.
Pefloxacin efficacy in gram-negative bacillary meningitis. J Antimicrob Chemother ;26 Suppl B Gram-negative cerebrospinal fluid shunt-associated infections. Pediatrics ; Comparative in vitro activity of SM, a new carbapenem antimicrobial agent. The intravitreal penetration of ceftriaxone in man following systemic administration. Shattuck KE, Chonmaitree T. The changing spectrum of neonatal meningitis over a fifteen-year period. Clin Pediatr ; Septic retinal cyst in endogenous Klebsiella endophthalmitis.
Am J Ophthalmol ; Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae : identification of CTX-1, a novel beta-lactamase. Failure of ceftazidime-amikacin therapy for bacteremia and meningitis due to Klebsiella pneumoniae producing an extended spectrum beta-lactamase. Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes. Decreased transmission of Enterobacteriaceae with extended-spectrum beta-lactamases in an intensive care unit by nursing reorganization.
Management of urinary tract infections in adults. N Engl J Med ; Ventriculoperitoneal shunt infections with Gram-negative bacteria. Neurosurg ; Klebsiella pneumoniae urinary tract infection complicated by endophthalmitis, perinephric abscess, and ecthyma gangrenosum. Cerebral abscess caused by Klebsiella ozaenae.
Investigation of the putative virulence gene magA in a worldwide collection of Klebsiella isolates: magA is restricted to the gene cluster of Klebsiella pneumoniae capsule serotype K1. J Med Microbiol ; Safety of imipenem in neonates.
Intravenous ciprofloxacin as treatment for patients with acute suppurative cholangitis: a randomized, controlled clinical trial. In vitro and in vivo activities of amikacin, cefepime, amikacin plus cefepime, and imipenbem against an SHV-5 extended-spectrum beta-lactamase producing Klebsiella pneumoniae strain.
In vitro activities of DQ, a potent quinolone, against clinical isolates. Klebsiella pneumoniae meningitis: prognostic factors. Scand J Infect Dis a Klebsiella ozaenae meningitis: report of two cases and review of the literature. Infect b; Hospital-acquired Klebsiella bacteremia.
Efficacies of piperacillin- tazobactam and cefepime in rats with experimental intra-abdominal abscesses due to an extended- spectrum beta-lactamase-producing strain of Klebsiella pneumoniae. Klebsiella pneumoniae endocarditis.
J Royal Soc Med ; Cefepime, piperacillin-tazobactam, and the inoculum effect in tests with extended-spectrum beta-lactamase-producing Enterobacteriaceae. Beta-lactamase production in members of the family Enterobacteriaceae and resistance to beta-lactam-enzyme inhibitor combinations. Comparative efficacy of ciprofloxacin, ceftazidime and gentamicin, given alone or in combination, in a model of experimental septicemia due to Klebsiella pneumoniae in neutropenic mice.
A case of rhinoscleroma cured by ciprofloxacin. Am J Med ;SS. Therapeutic studies of cefepime BMY in murine meningitis and pharmacokinetics in neonatal rats. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as aherald for community-acquired infection. Arch Intern Med ; Correlation between the in vitro and in vivo effects of fourteen beta-lactam compounds in mice with systemic infection.
CTX-M-type beta-lactamases: an emerging group of extended-spectrum enzymes. Int J Antimicrob Agents ; Klebsiella bacteremia in cancer patients. Gram-negative enteric bacillary meningitis: a twenty-one year expereince.
J Pediatr ; Antimicrobial drugs, microorganisms, and phagocytes. Ex vivo pharmacodynamic study of piperacillin alone and in combination with tazobactam, compared with ticarcillin plus clavulanic acid. Serum bactericidal activity of ceftazidime and cefoperazone alone or in combination with amikacin against Pseudomonas aeruginosa and Klebsiella pneumoniae.
The penetration of ceftazidime into the inflamed rabbit eye. Scand J Infect Dis ; Klebsiella pneumoniae bacteremia: analysis of episodes. Watanakunakorn C, Jura J. Klebsiella bacteremia: a review of episodes during a decade Ciprofloxacin: a comparative evaluation of its bactericidial activity in human serum against four enterobacterial species.
Drugs Under Exp Clin Research ; The in vitro activity of BMS, a new des- fluorinated quinolone. Multiple antibiotic- resistant Klebsiella and Escherichia coli in nursing homes. Wojsyk-Banaszak I, Szczapa J. Central nervous system infections in neonates caused by multiresistant Klebsiella pneumoniae. Ginekol Pol ; Outbreak of infection with multidrug-resistant Klebsiella pneumoniae carrying bla IMP-8 in a university medical center in Taiwan. Mag A is not a specific gene for Klebsiella pneumoniae strains causing liver abscess but is a part of the capsular polysaccharide gene cluster of K.
Serotype K1 capsule, rather than magA per se, is really the virulence factor in Klebsiella pneumoniae strains that cause primary pyogenic liver abscess. Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
In vitro and in vivo studies of three antibiotic combinations agaisnt gram-negative bacteria and Staphylococcus aureus. Collated from the references 21 , 26 , 29 , 30 , 48 , 92, 95 , 96 , , , , , , , ,. Collated from references 92, , , , , Outer membrane protein loss plus extended-spectrum beta-lactamase or plasmid-mediated AmpC beta-lactamase. When colonies were touched with a loop and the loop lifted vertically from the surface of the agar palte, mucoid isolates adhered to the loop as it was lifted from the plate Figure first presented at the 36th Annual Conference of the Infectious Diseases Society of America, Denver, Colorado, USA, Giamarellou H, et al.
Double-carbapenem regimen for carbapenemase-producing pandrug-resistant Klebsiella pneumoniae infections: Is it really effective in humans? Antimicrob Agents Chemother ; [Epub ahead of print]. Qureshi ZA, et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: Superiority of combination antimicrobial regimens.
Antimicrob Agents Chemother. Siu LK, et al. Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis ; J Infect Dis. Lancet Infect Dis. The spread of Klebsiella pneumoniae carbapenemases: a tale of strains, plasmids, and transposons. Clinical Manifestations. Laboratory Diagnosis. Baron EJ. Turner S, et al. Bush K, et al. Golnaz J, Zuravleff J. Retinitis and Endophthalmitis.
Pitout JD. Infect Med ; Klebsiella species K. K lebsiella oxytoca K. K lebsiella rhinoscleromatis In vitro studies have been performed on 23 clinical isolates of K.
K lebsiella ozaenae Limited in vitro data on antibiotic susceptibility of K. C ombination Drugs In Vitro for Klebsiella pneumoniae The addition of beta-lactamase inhibitors to beta-lactams is well known to result in enhanced activity of the beta-lactams against beta-lactamase producing strains of K.
0コメント